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Blisters or bullas are bubbles of fluid that forms beneath a thin layer of dead skin. The fluid is a mixture of water and proteins that oozes from injured tissue.

They most generally form in response to a specify injury and usually involve only the topmost layers of skin. Examples of these injuries are a burn or irritation.

Those that develop as part of a systemic disease may start in the deeper layers of the skin and cover widespread areas. These blisters heal more slowly and may leave scars.

Autoimmune Diseases that cause Blisters


This is a rare, severe disease in which blisters of varying sizes break out on the skin, the lining of the mouth, the genitals, and other mucous membranes. It most often develops in middle-aged or older people, rarely in children.

Bullous Pemphigoid

This is a disease that causes blistering of the skin. It tends to occur mainly in older people, is less serious than pemphigus, is rarely fatal, and doesn’t result in widespread peeling of the skin.

Dermatitis Herpetiformis

This is a disease that causes clusters of intensely itchy small blisters and hivelike swellings. It has nothing to do with the herpes virus. In people who have this disease, glutens or proteins in wheat, rye, and barley products somehow activate the immune system, which attacks parts of the skin and causes rash and itching.

Blisters Measuring About 10 Cm Across in Boiling Mud Pool, Yellowstone National Park, Wyoming
Blisters Measuring About 10 Cm Across in Boiling Mud Pool, Yellowstone National Park, Wyoming

Photographic Print
Waltham, Tony
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The information on is not offered for the diagnosis, cure, mitigation, treatment, or prevention of any disease or disorder nor have any statements herein been evaluated by the Food and Drug Administration (FDA). We strongly encourage you to discuss topics of concern with your health care provider.

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